POVIDONE-IODINE SOLUTION IP 5% W/V

Povidone-Iodine Solution IP 5% w/v is a broad-spectrum topical antiseptic and disinfectant. The “IP” designation indicates that the product complies with the quality standards set by the Indian Pharmacopoeia.

Below is a detailed description of its composition, mechanism, and usage.

1. Composition

• Active Ingredient: Povidone-Iodine IP $5\%$ w/v (Weight/Volume).

• Available Iodine: Usually contains approximately $0.5\%$ w/v available iodine.

• Formulation: It is an aqueous (water-based) solution. It often includes inactive ingredients like purified water, buffering agents (e.g., Sodium Phosphate, Citric Acid), and stabilizers.

• Physical Appearance: A dark, reddish-brown liquid with a faint, characteristic odor of iodine.

2. Mechanism of Action

Povidone-Iodine is an iodophor, a complex of the polymer povidone and elemental iodine.

• Slow Release: The povidone polymer acts as a reservoir, slowly releasing “free iodine” into the skin or wound.

• Microbicidal Effect: Free iodine quickly penetrates the cell walls of microorganisms and oxidizes critical proteins, nucleotides, and fatty acids, leading to cell death.

• Spectrum: It is effective against a wide range of pathogens, including:

  • Gram-positive and Gram-negative bacteria.

  • Fungi and yeasts.

  • Viruses.

  • Protozoa.